Environmental Pollutants as Toxic Signals (Part 1): Understanding the Hidden Threats to Your Brain Health, Nervous System, and Well-Being

Think of your nervous system as a high-speed train system—efficient, precise, and designed to keep everything running on schedule. Messages zip from your brain to your body like bullet trains, ensuring you can think, move, and function without delays. But what happens when environmental pollutants sneak onto the tracks? Imagine lead as a pile of debris blocking the rails, pesticides as faulty signals potentially sending trains in the wrong direction, and air pollution as the mysterious fog that slows everything down. The result? A possible risk of delayed reactions, misfired messages, and a nervous system that feels more like a slow subway than a world-class express.

In this article, we’ll explore how hidden pollutants may disrupt your neurological transit system, what the latest science says about their long-term effects, and how you can clear the tracks for smoother operation. Specifically, we’ll discuss key pollutants such as heavy metals (including lead, mercury, and arsenic), persistent organic pollutants (POPs) like perchlorate (used in dry cleaning), per- and polyfluoroalkyl substances (PFAS) like perfluooctanoic acid used in production of teflon and nonstick cookware, and polychlorinated biphenyls (PCBs) used in electrical equipment and adhesives;  particulate matter (PM2.5), polycyclic aromatic hydrocarbons (PAHs); and endocrine disrupting chemicals (EDCs) like bis-phenol A, commonly found in plastics and thermal paper such as receipts. We will also examine the range of cognitive, motor, and sensory impairments these pollutants can induce, and which groups—including children, pregnant women, and those in low-income countries—are particularly vulnerable.

I recommend that my coaching clients check their levels of toxins as well as the genomic drivers of detoxification to see if they might be more vulnerable. Here is an example of a recent toxin burden urine test from a client that shows high levels of bis-phenol A and suboptimal levels of arsenic.

As we explore the impact of environmental exposures on the nervous system, we will cover the following topics in two parts.

• Preventative measures that can be taken
• Environmental pollutants affecting the nervous system
• Symptoms associated with exposure
• Populations that may face the greatest risk
• Available diagnostic tests

Exposure to environmental pollutants can have substantial neurotoxic effects on the nervous system. Heavy metals, including lead, mercury, and arsenic, are well-established neurotoxicants. These metals can induce neurotoxic effects through mechanisms like oxidative stress, neuroinflammation, and disruption of neurotransmitter systems. Persistent organic pollutants (POPs), which include polychlorinated biphenyls (PCBs) and per- and polyfluoroalkyl substances (PFAS), can cross the blood-brain barrier and are associated with neurodevelopmental and neurodegenerative disorders. Particulate matter (PM), especially fine particulate matter (PM2.5), is another significant pollutant that can induce oxidative stress and neuroinflammation, contributing to conditions such as Alzheimer’s and Parkinson’s diseases. Polycyclic aromatic hydrocarbons (PAHs), present in sources like tobacco smoke and vehicle exhaust, are also linked to neurotoxicity through mechanisms such as oxidative stress and DNA damage. 

The Devils We Know

Understanding the specific pollutants is crucial to grasping the scope of the problem. These substances infiltrate our environments in various ways, often with insidious long-term effects.

Environmental pollutants that harm the nervous system include several key categories. One major group of culprits is heavy metals, including lead, mercury, and arsenic, which can harm the brain by causing inflammation, stress at the cellular level, and disrupting the chemicals in our brain that help us think and feel. Other significant pollutants include:

• Persistent organic pollutants: These include chemicals like PCBs and PFAS, which can cross into the brain and cause problems with how our nervous system develops and functions, sometimes leading to diseases like Alzheimer’s or Parkinson’s.
• Particulate matter: Tiny particles in the air, especially fine particulate matter (PM2.5), can travel deep into the lungs and into the bloodstream, causing inflammation and damage to the brain. This can contribute to cognitive decline and other neurological issues.
• Polycyclic aromatic hydrocarbons: These pollutants, found in things like car exhaust and tobacco smoke, can also damage brain cells and DNA, increasing the risk of developing diseases that affect the brain over time.
• Endocrine disruptors: Endocrine-disrupting chemicals are known to interfere with the endocrine system, which can lead to significant neurodevelopmental and neurotoxic effects. These chemicals can cross the placenta and affect the developing fetal brain, leading to long-term consequences on neurodevelopment and behavior. For instance, gestational exposure to EDCs such as bisphenol A (BPA) have been associated with altered neuroendocrine control, neurotransmitter function, and behaviors such as learning, memory, and social interactions. Animal studies have shown that prenatal exposure to BPA and di(2-ethylhexyl) phthalate (DEHP) can lead to significant changes in brain histopathology, neurotransmitter levels, and enzyme activities, indicating neurotoxicity.

Common Symptoms

The effects of these pollutants manifest in a wide range of neurological symptoms, highlighting the systemic damage they can cause. Exposure to these pollutants can lead to a variety of symptoms or exposure may be asymptomatic.

• Heavy metals:
  • Lead: Cognitive deficits, impaired memory, attention disorders, and decreased IQ. Chronic exposure can lead to encephalopathy, characterized by headaches, confusion, and seizures.  
  • Mercury: Sensory disturbances, ataxia, tremors, and cognitive impairments. Chronic exposure can lead to Minamata disease, characterized by severe neurological and developmental deficits.  
  • Arsenic: Peripheral neuropathy, cognitive dysfunction, and motor impairments. Chronic exposure can lead to neurodevelopmental delays in children.  
• Persistent organic pollutants: Cognitive deficits, memory impairment, and neurodevelopmental disorders such as ADHD and autism spectrum disorders (ASD).  
• Per- and polyfluoroalkyl substances (PFAS): Cognitive impairments, decreased IQ, and developmental neurotoxicity.  
• Particulate matter: Cognitive decline, memory impairment, and increased risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Symptoms include decreased cognitive function, motor deficits, and increased incidence of depression and anxiety.  
• Polycyclic aromatic hydrocarbons: Cognitive impairments, memory deficits, and increased risk of neurodevelopmental disorders. Chronic exposure can lead to oxidative stress and neuroinflammation, contributing to neurodegenerative diseases.  
• Endocrine disrupting chemicals: Symptoms may include cognitive deficits, behavioral changes, and increased risk of neurodevelopmental disorders like autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD).

These symptoms are primarily mediated through mechanisms such as oxidative stress, neuroinflammation, disruption of neurotransmitter systems, and interference with cellular signaling pathways.

Which Populations Are at Greatest Risk?

Certain groups within our society face a disproportionate burden of exposure, amplifying the urgency of addressing environmental injustice. Certain populations are more vulnerable:

• Children: Exposure to neurotoxicants during critical periods of brain development can lead to long-term cognitive and behavioral deficits. Studies have shown that children from low-income families and racial/ethnic minority groups are disproportionately affected by these exposures.  
• Pregnant Women and Fetuses: Prenatal exposure to neurotoxicants can adversely affect fetal brain development, leading to neurodevelopmental disorders such as ADHD and autism spectrum disorders. Maternal exposure to pollutants like lead, mercury, and PCBs has been associated with adverse neurodevelopmental outcomes in offspring.  
• Residents of Low and Middle-Income Countries: Populations in these countries are at higher risk due to higher levels of environmental pollution and limited regulatory controls. Children in these regions are particularly susceptible to the neurotoxic effects of heavy metals such as lead and manganese.  
• Urban Populations: Individuals living in highly polluted urban areas are at increased risk due to higher exposure to particulate matter and industrial pollutants. For example, residents of Metropolitan Mexico City have shown early neuropathological changes associated with neurodegenerative diseases due to exposure to fine particulate matter and industrial nanoparticles.  
• Occupationally Exposed Individuals: Workers in industries such as mining, manufacturing, and agriculture may be exposed to higher levels of neurotoxicants, increasing their risk of nervous system damage.

These populations are at heightened risk due to a combination of increased exposure and greater vulnerability during critical periods of development or due to socioeconomic factors that limit access to healthcare and mitigation resources.

Conclusion

The evidence is clear: environmental pollutants pose a significant threat to neurological health, with certain populations facing disproportionately higher risks. Understanding these dangers is the first step towards creating safer environments and protecting vulnerable individuals. The impact of these pollutants is far reaching, and requires increased public awareness, and policy changes to mitigate their effects.

If you want to test yourself for environmental pollutants, consider the Total Tox Burden test by Vibrant Labs. I’ve shared a de-identified client’s results.

In Part 2, learn more about the diagnostic tests available and preventative measures you can take to protect yourself and your loved ones from these environmental neurotoxins.

References:

Costa, L. G., T. B. Cole, K. Dao, et al. “Effects of Air Pollution on the Nervous System and Its Possible Role in Neurodevelopmental and Neurodegenerative Disorders.” Pharmacology & Therapeutics 210 (2020): 107523. https://doi.org/10.1016/j.pharmthera.2020.107523.

de Paula Arrifano, G., M. E. Crespo-Lopez, A. Lopes-Araújo, et al. “Neurotoxicity and the Global Worst Pollutants: Astroglial Involvement in Arsenic, Lead, and Mercury Intoxication.” Neurochemical Research 48, no. 4 (2023): 1047–65. https://doi.org/10.1007/s11064-022-03725-7.

Fang, Y., L. Lu, Y. Liang, et al. “Signal Transduction Associated With Lead-Induced Neurological Disorders: A Review.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 150 (2021): 112063. https://doi.org/10.1016/j.fct.2021.112063.

Fu, C., D. Kuang, H. Zhang, J. Ren, and J. Chen. “Different Components of Air Pollutants and Neurological Disorders.” Frontiers in Public Health 10 (2022): 959921. https://doi.org/10.3389/fpubh.2022.959921.

Gade, M., N. Comfort, and D. B. Re. “Sex-Specific Neurotoxic Effects of Heavy Metal Pollutants: Epidemiological, Experimental Evidence and Candidate Mechanisms.” Environmental Research 201 (2021): 111558. https://doi.org/10.1016/j.envres.2021.111558.

Hyun, S. A., and M. Ka. “Bisphenol A (BPA) and Neurological Disorders: An Overview.” The International Journal of Biochemistry & Cell Biology 173 (2024): 106614. https://doi.org/10.1016/j.biocel.2024.106614.

Iqubal, A., M. Ahmed, S. Ahmad, et al. “Environmental Neurotoxic Pollutants: Review.” Environmental Science and Pollution Research International 27, no. 33 (2020): 41175–98. https://doi.org/10.1007/s11356-020-10539-z.

Kajta, M., and A. K. Wójtowicz. “Impact of Endocrine-Disrupting Chemicals on Neural Development and the Onset of Neurological Disorders.” Pharmacological Reports: PR 65, no. 6 (2013): 1632–39. https://doi.org/10.1016/s1734-1140(13)71524-x.

Nesan, D., and D. M. Kurrasch. “Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior.” Annual Review of Physiology 82 (2020): 177–202. https://doi.org/10.1146/annurev-physiol-021119-034555.

Peixoto-Rodrigues, M. C., J. R. Monteiro-Neto, T. Teglas, et al. “Early-Life Exposure to PCBs and PFAS Exerts Negative Effects on the Developing Central Nervous System.” Journal of Hazardous Materials 485 (2025): 136832. https://doi.org/10.1016/j.jhazmat.2024.136832.

Raja, G. L., et al. “In Utero Exposure to Endocrine Disruptors and Developmental Neurotoxicity: Implications for Behavioural and Neurological Disorders in Adult Life.” Environmental Research 203 (2022): 111829. https://doi.org/10.1016/j.envres.2021.111829.

Roy, R., and A. D’Angiulli. “Air Pollution and Neurological Diseases, Current State Highlights.” Frontiers in Neuroscience 18 (2024): 1351721. https://doi.org/10.3389/fnins.2024.1351721.

Shabani, S. “A Mechanistic View on the Neurotoxic Effects of Air Pollution on Central Nervous System: Risk for Autism and Neurodegenerative Diseases.” Environmental Science and Pollution Research International 28, no. 6 (2021): 6349–73. https://doi.org/10.1007/s11356-020-11620-3.

Szal, Sara (formerly Gottfried). The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality Naturally with the Gottfried Protocol. New York: HarperCollins, 2013. The Hormone Cure: Reclaim Balance, Sleep, Sex Drive and Vitality Naturally with the Gottfried Protocol

Xu, P., B. Liu, H. Chen, et al. “PAHs as Environmental Pollutants and Their Neurotoxic Effects.” Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP 283 (2024): 109975. https://doi.org/10.1016/j.cbpc.2024.109975.

Yirun, A., et al. “Neuroendocrine Disruption by Bisphenol A and/or Di(2-Ethylhexyl) Phthalate After Prenatal, Early Postnatal and Lactational Exposure.” Environmental ¹ Science and Pollution Research International 28, no. 21 (2021): 26961–26974. https://doi.org/10.1007/s11356-021-12408-9.  

1. ivgcm.hacettepe.edu.tr

ivgcm.hacettepe.edu.tr

Yu, G., L. Wu, Q. Su, et al. “Neurotoxic Effects of Heavy Metal Pollutants in the Environment: Focusing on Epigenetic Mechanisms.” Environmental Pollution (Barking, Essex : 1987) 345 (2024): 123563. https://doi.org/10.1016/j.envpol.2024.123563.